The pair picked the injuries during the Tricolores pre-season friendly encounter against VVCS on Saturday.
Wriedt was left with a broken metatarsal bone in his left foot from the game.
Owusu meanwhile had to leave the field with a hamstring injury.
Research in the hospital has shown that neither player can take action in the short term.
Wriedt joined the Dutch top-flight club on a free transfer after ending his stay with German Bundesliga powerhouse Bayern Munich this summer.
Owusu also moved to the Koning Willem II Stadion from De Graafschap this summer.
The 23-year old right-back joins the club on a three year deal.
The former Ajax Academy graduate and Excelsior man was in fine form for De Graafschap before the season was cancelled, scoring 3 and providing 5 assists in 29 appearances.
The duo could miss the side’s opening fixture of the Dutch top-flight on September 12.
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